Cerebral blood flow velocity and white matter changes in type 2 diabetes mellitus
Hu K, Last D, Alsop D, Abduljalil A, Robles C, Novak V, Cavallerano J, Lepicovsky L, Lipsitz L
Beth Israel Deaconess Medical Center, Harvard Medical School
Diabetes mellitus (DM) increases the risk for cerebrovascular disease, through the effects on cerebral microvasculature and blood flow regulation. This study addresses the effects of type 2 DM on cerebrovascular responses to CO2 challenges and the relationship between white matter changes (WMC) on MRI and cerebral blood flow velocity (BFV) using transcranial Doppler ultrasound in elderly people. BFV was reduced with type 2 DM. Low BFVs were significantly associated with WMC. These investigations may disclose early indicators of cerebrovascular disease.