A New Complex of Diperoxovanadate with 2-(2&[prime]-pyridyl)-imidazole: Synthesis, Structure, Interaction and Bioactivity
Yan J, Yang S, Li X, Cai S, Chen Z, Pan Y
A new diperoxovanadate complex NH4[OV(O2)2(2-(2&[prime]-pyridyl)-imidazole)]&[middot]4H2O was synthesized. Its solution structure was characterized by multinuclear (1H, 13C, 14N, and 51V) as well as multi-dimensional (DOSY and C-H COSY) NMR techniques in the interaction system of NH4VO3/H2O2/2-(2&[prime]-pyridyl)-imidazole at room temperature. It affected the proliferation of tumor cell and normal one in a different manner. In addition, it inhibited the specific activity of ALP (alkaline phosphatase) in gastric cancer cell MGC-803.