OVS-localized 31P NMR spectroscopy in the primate brain
Valette J, Guillermier M, Hantraye P, Lebon V
In this work 31P NMR spectroscopy is performed in the monkey brain using a surface coil at 3T. Optimized localization is achieved in an 8mL cubic voxel at zero echo time by Outer Volume Suppression, with no signal loss caused by metabolites fast T2 relaxation, and negligible contamination from muscle. This localization technique proves to be sensitive enough for combination with inversion-recovery and saturation transfer and subsequent measurement of ATP synthesis rate in the primate brain at 3T.