19F high senseitivity imaging for in vivo drug dynamics in mice at 7T with 5-FU
Kanazawa Y, Ando K, Hirano Y, Koike S, Narazaki M, Fujiita M, Onozuka M, Ikehira H, Yoshitome E
Institute of Radiological Sciences
High sensitivity 19F imaging in small animals is demonstrated using fast sequences such as FSE and FISP at 7T. Dynamical study of 5-FU was successful by FSE with chemical shift selective pulses for simultaneous imaging of several resonance lines by interleave. Clear image of anabolites Fnuc was shown at the position of tumors by FSE. The advantage and disadvantage of FISP is discussed. The method will also find an extended use for molecular imaging.