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Abstract #3445

A combined VBM and DTI investigation of brain structure and connectivity in 22q11 Deletion Syndrome

Chaddock C, Lee L, Newton J, Baldeweg T, Frackwoiak R, Skuse D
Institute of Psychiatry

22q11 deletion syndrome is a genetic syndrome associated with increased rates of schizophrenia. Voxel Based Morphometry and Diffusion Tensor Imaging techniques were used to investigate brain structure. Grey matter density was reduced in the cingulate and bilaterally in the temporal lobes, whilst increases were seen in the insula. White matter density was reduced bilaterally in middle and superior frontal gyri, whereas increases were seen posteriorally to the corpus callosum. DTI data provided evidence of disrupted WM coherence in fronto-temporal areas, although further work is needed to understand how GM and WM loss affects the anatomical location of WM tracts.