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Abstract #3446

A Correlational Analysis of Cognitive fMRI, DTI, and Clinical Assessment of Multiple Sclerosis

Goodyear B, Lau R
University of Calgary

To date, MR imaging studies of Multiple Sclerosis have not investigated the inter-relationship of cognitive fMRI and white matter integrity as measured by DTI, as well as their correlation with current clinical assessments. Understanding these inter-relationships may provide a more complete description of the progression of MS, and could lead to an imaging protocol that, in combination with behavioral assessment, is a comprehensive and accurate clinical evaluation. The objective of this study was to identify correlations between existing clinical measures of MS severity with brain activity measured using fMRI and with ROI-based measurements of fractional anisotropy.