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Abstract #3448

Diffusion Weighted Imaging of Ocular Adnexal Lymphomas: usefulness in differential diagnosis and early predictor of response to therapy

Ferreri A, Pieralli S, Anzalone N, Falini A, Scotti G, Politi L, Vezzulli P, Bianchi S
San Raffaele

We assess feasibility and optimal MR parameters of Diffusion Weighted Imaging (DWI) of the orbits. We demonstrated clinical usefulness of DWI in the diagnosis of Ocular Adnexal Lymphomas (OAL). OAL show ADC values (610 +/- 54 x 10-6 mm2/sec) significantly lower than other orbital diseases (p<0.01) and normal orbital structures (p<0.002). Further, changes in ADC could represent an additional helpful tool for monitoring the outcome of OAL and predicting response to therapy, since an increase in ADC value precedes volumetric reduction of the lesion.