Accuracy of assuming uniform temporal sampling in the analysis of cardiac perfusion MRI datasets
DiBella E, Kholmovski E
University of Utah
Myocardial perfusion studies acquire images of multiple slices in each heart beat. It is typically assumed that the bolus tracking images are uniformly sampled in time. This is often not an accurate assumption, due to missed triggers and heart rate changes. This work shows that up to ~20% change in regional perfusion estimates from a two compartment model or the upslope analysis method is possible from assuming uniform temporal sampling. Larger errors were found with an adenosine stress pre-bolus study. Temporal sampling information should be included in the processing of dynamic contrast enhanced cardiac perfusion studies.