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Abstract #3594

Diffuse and Heterogenous Systolic Dysfunction in Hypertrophic Cardiomyopathy with Myocardial Tagging

Choi B, Haber I, Maron M, Manning W, Yeon S
Beth Israel Deaconess Hospital, Yonsei University College of Medicine

Hypertrophic cardiomyopathy (HCM) is characterized by myocardial hypertrophy, which may be associated with myocyte disarray and fibrosis. These structural abnormalities may cause ventricular systolic and diastolic dysfunction. However, the relationship between structural and functional abnormalities has not yet been well defined. In a cohort of subjects with HCM, we studied the extent and pattern of left ventricular systolic impairment as assessed by tagged CMR in relation to wall thickness and delayed enhancement. Systolic dysfunction in HCM is regionally heterogeneous and involves hypertrophied as well as nonhypertrophied segments. MPS is positively correlated with EDWT. The epicardial layer shows dysfunction more frequently than mid or endocardial layer. Tagged MRI may be helpful for detection of transmural and nontransmural dysfunction in nonhypertrophied and hypertrophied segments.Delayed enhancement was frequently found in septal junction regions and in segments with marked hypertrophy, which showed m