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Abstract #0957

Is R2* in Human Brain White Matter Dependent on B0 Orientation?

Tie-Qiang Li1, Fukunaga Masaki2, Stephen Dodd2, Peter van Gelderen2, Merkle Hellmut2, Jeff H. Duyn2

1Medical Physics, Karolinska Huddinge, Stockholm, Sweden; 2NINDS, NIH, Bethesda, MD, USA

The observation of T2* heterogeneity in white matter at high magnetic field strength [1] has invited speculation that white matter fiber orientation with respect to the main magnetic field (B0) might contribute to this contrast. To investigate this, we performed quantitative R2* measurements at different orientations in vivo and in fixed brain tissue samples.