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Abstract #1017

MRI Characteristics of Primitive Neuroectodermal Tumors (PNETs) in a Spontaneous JCV T-Antigen Transgenic Mouse Brain Tumor Model at 7 Tesla

Feroze B. Mohamed1, Harvey Hensley2, Luis Del Valle3, Linda Knight, Chris Conklin, Kamal Khalili3, Scott H. Faro, Jennifer Gordon3

1Radiology, Temple University, Philadelphia, PA, USA; 2Fox Chase Cancer Center; 3Neuroscience, Temple University

Medulloblastomas and primitive neuroectodermal tumors (PNETs), are highly cellular malignant primary brain tumors representing the most common solid tumors arising in children. Currently, to our knowledge, realistic animal models to study the in-vivo imaging characteristics of these tumors are lacking. In this work we have developed and studied the MR imaging characteristic of these PNETs in a spontaneous JCV T-antigen transgenic mouse brain tumor model at 7 Tesla.