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Abstract #1146

Prediction of Persistent and Transient T1 black Holes in Multiple Sclerosis Using MRI Texture Analysis

Yunyan Zhang1, Anthony Traboulsee1, Yinshan Zhao1, Luanne M. Metz2, David KB Li3

1Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada; 2Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada; 3Department of Radiology, University of British Columbia, Vancouver, British Columbia, Canada

3T MRI texture analysis using the polar Stockwell Transform (PST) was applied to 15 new acute T1 black holes (BHs) at baseline from 9 multiple sclerosis (MS) patients. PST texture was calculated for each pixel of lesional ROIs and 9 NAWM regions. Texture spectrum differed between lesions and NAWM. The low frequency energy was higher and span broader in persistent BHs than in transient BHs (P < 0.05). These results suggest that the PST texture analysis may have the potential to predict trueBH from tranBH at the time of lesion formation, months before visible evolution.