Calibration of ASL Quantification Based on Hypercapnia and Sensory Motor Activation

Sumiko Abe¹, Jerod Michael Rasmussen¹, Jessica Turner¹, L. Ch McMillan¹, Josef Pfeuffer², F. BIRN³

To evaluate the feasibilities of quantifying cerebral perfusion with dynamic magnetic resonance artery spin labeling (ASL) sequence, we studied 4 subjects under BH and CB activities for evaluating the correlations of CBF with CMRO2 and M coefficient (i.e. CBV) with CMRO2. Based on analysis results, we confirmed that BH task increased CBF and it is not significant or weak effects to CMRO2 changes. CB task doesnt increase the GM CBF as much as BH task but CMRO2 is increased significantly due to CBF and M increasing in specified areas such as vision and motor areas.