Stefan A. Carp1, David A. Boas1, Maria A. Franceschini1, Bruce Ro Rosen1, Young Ro Kim1
1Athinoula Martinos Center for Biomedical Imaging/ Massachusetts General Hospital, Charlestown, MA, USA
Direct measurement of variations in the cerebral metabolic rate of oxygen (CMRO2) can be very useful in the study of neuro-vascular coupling in various disease states. We attempt to validate near-infrared optical measurements of cerebral blood volume and blood flow in a rat model during hypercapnia using functional MRI, with the purpose of developing a non-invasive method for measuring relative CMRO2 changes.