Abstract #1626

Validation of Optical Measurements of Cerebral Blood Flow and Volume with SPION and ASL FMRI: Implications for CMRO2 Changes During Hypercapnia

Stefan A. Carp¹, David A. Boas¹, Maria A. Franceschini¹, Bruce Ro Rosen¹, Young Ro Kim¹

¹Athinoula Martinos Center for Biomedical Imaging/ Massachusetts General Hospital, Charlestown, MA, USA

Direct measurement of variations in the cerebral metabolic rate of oxygen (CMRO2) can be very useful in the study of neuro-vascular coupling in various disease states. We attempt to validate near-infrared optical measurements of cerebral blood volume and blood flow in a rat model during hypercapnia using functional MRI, with the purpose of developing a non-invasive method for measuring relative CMRO2 changes.