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Abstract #1743

Estimation of the Myocardial Extracellular Volume Fraction from Dynamic Contrast-Enhancement Measurements and Comparison with Partition Coefficient Measurements

Michael Jerosch-Herold1, Ray E. Hershberger2, Craig Broberg3

1Radiology, Brigham & Women's Hospital, Boston, MA, USA; 2Medicine, University of Miami Miller School of Medicine, Miami, FL, USA; 3Medicine, Oregon Health & Science University, Portland, OR, USA

T1 measurements after contrast administration have been shown to provide a novel marker of diffuse fibrosis and remodeling of the extracellular matrix. In this study we tested the hypothesis that multiple T1 measurements for determination of the partition coefficient can be replaced with a single dynamic contrast enhancement study for determination of the extracellular volume fraction. The two methods were found to agree well. Multi-slice measurements of myocardial contrast enhancement by dynamic imaging provide an efficient method to determine the distribution volume for an extracellular contrast agent, compared to multiple T1 measurements.