Abstract #2093

MR Quantification of Abnormal Stromal Enhancement in the Periphery of Invasive Breast Tumors

Nima Nabavizadeh^1,2, Catherine Klifa¹, David Newitt¹, Ying Lu¹, Jona Hattangadi³, Clark Fisher², Nola Hylton¹, Catherine Park²

¹Radiology, University of California, San Francisco, San Francisco, CA, USA; ²Radiation Oncology, University of California, San Francisco, San Francisco, CA, USA; ³Radiation Oncology, Harvard Medical School, Boston, MA, USA

In this study, we hypothesized that abnormalities in vasculature exist within the histologically normal appearing periphery of breast tumors that can be detected by measuring changes in MR enhancement intensity. Using breast tissue proximity maps and percent enhancement values obtained from dynamic contrast-enhanced MRIs, we found that the normal breast stroma within 0 to 2cm of a primary tumor exhibits higher enhancement levels than stroma located far from the tumor region. These results suggest that tissue surrounding the tumor region may contain vasculature abnormalities or tumor-related angiogenesis, which could potentially help refine surgery and radiation therapy for breast cancer.