Abstract #2138

Simultaneous Changes in Liver Volume, Lipid Content and Glycogen Content in Type 2 Diabetes, Obese Subjects and Normal Controls After a Mixed Meal

Mary Charlotte Stephenson¹, Emily Leverton¹, Eric Y. Khoo², Jane Halliday³, Simon M. Poucher³, Lars Johansson^4,5, Jan W. Eriksson^4,6, Roy Taylor⁷, Peter Mansell², Ian A. Macdonald², Peter Gordon Morris¹

¹SPMMRC, School of Physics and Astronomy, University of Nottingham, Nottingham, UK; ²School of Biomedical Sciences,, University of Nottingham, Nottingham, Nottinghamshire, UK; ³AstraZeneca, Macclesfield, UK; ⁴AstraZeneca, Molndal, Sweden; ⁵Dept of Radiology, Uppsala University Hospital, Uppsala, Sweden; ⁶Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden; ⁷School of Clinical Medical Sciences, University of Newcastle, Newcastle, UK

Metabolic disturbances in diabetes are known to include impaired storage of glycogen and may include perturbed lipid metabolism. The purpose of the study was to observe changes in hepatic lipid and glycogen in response to two mixed meals, in four different groups, with varying degrees of metabolic dysfunction. Basal glycogen levels were found to be reduced in diabetic and healthy obese subjects when compared with normal weight healthy subjects. Attenuated postprandial increases also suggested lower ability to store glycogen. Increased hepatic lipid levels measured in the diabetic groups could not be explained solely by increased obesity indicating perturbed lipid metabolism.