Abstract #2139

High-Resolution Magic Angle Spinning 1H MRS Detects Lipid Biomarkers in Liver After High Fat Diet

Haihui Cao^1,2, Jussi Pihlajamaki³, Mary-Elizabeth Patti³, A Aria Tzika^1,2

¹NMR Surgical Laboratory, MGH & Shriners Hospitals, Harvard Medical School, Boston, MA, USA; ²Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Boston, MA, USA; ³Research Division, Joslin Diabetes Center at Harvard Medical School, Boston, MA, USA

We report that high-resolution Magic Angle Spinning (HRMAS) 1H MRS has detected lipid accumulation in liver of mice fed with high fat diet. Our findings are consistent with the hypothesis that HRMAS 1H NMR permits the identification of novel lipid biomarkers, which can allow early diagnosis and could greatly improve prognosis in obesity, insulin resistance and type II diabetes.