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Abstract #2321

Tissue Metabolic Concentrations Investigated with Respect to Prognosis for Breast Cancer Patients

Beathe Sitter1, Tone Frost Bathen1, Hans Fjsne2, Jostein Halgunset3, Steinar Lundgren1,4, Ingrid Susann Gribbestad1

1ISB, NTNU, Trondheim, Norway; 2Dept. of Surgery, Trondheim University Hospital, Trondheim, Norway; 3LBK, NTNU, Trondheim, Norway; 4Dept. of Oncology, Trondheim University Hospital, Trondheim, Norway

In the search for improved treatment and care for breast cancer patients, understanding breast cancer biology is important. For molecular mechanisms studied in vitro to be translated to clinical use, metabolic information should relate to clinically relevant parameters. Breast cancer tissue metabolic concentrations have been quantified and directly correlated to prognostic factors and patient outcome. Biopsies from diseased patients have higher concentrations of choline than samples from patients with good and poor prognosis. Trend towards significance were found for lower GPC in the good prognosis group and higher PC in diseased group compared to poor prognosis group. Significant differences between groups of samples were also found for ratios of GPC/Gly and PC/GPC.