Effect of Acute Hyperglycemia with Octreotide on Intra-Renal Oxygenation as Estimated by BOLD MRI in Rats

Lu-Ping Li¹, Joann Carbray¹, Sarah Halter¹, Pottumarthi V. Prasad¹

Previous observations have shown lower intra-renal oxygenation early after induction of type I diabetes. In order to test the hypothesis that this may be related to direct effect of hyperglycemia, infusion of glucose solution was used in healthy rats. While a statistically significant but modest increase in R2* (and blood glucose) was observed, they were not comparable to those in diabetic rats. In this study, pretreatment with an insulin inhibitor (octreotide) was used to produce sustained and higher level of acute hyperglycemia in rats. Both blood glucose and R2* showed a significant and comparable increase to those in diabetic rats.