Microperfusion-Induced Elevation of ADC Is Suppressed After Contrast in Breast Carcinoma

Sachiko Yuen¹, Mariko Goto¹, Kei Yamada¹, Akiko Takahata¹, Kaori Nishida¹, Tsunehiko Nishimura¹

Post-contrast ADC exhibited a significant lower value (-23%, p=0.01) than pre-contrast ADC in breast carcinoma, which is thought to reflect the suppression of the microperfusion-induced effect on DWI. When early post-contrast images were used as a surrogate marker of tumor aggressiveness, we found a significant inverse correlation with the post-contrast ADC ( = -0.57, p=0.02). Post-contrast ADC may be a better indicator to reflect the aggressiveness of tumors.