Breast Tissue Classifications by CART Analysis of Localized 2D COSY

Xiaoyu Liu¹, Scott lipnick¹, James Sayre¹, Shida Banakar¹, Nanette Debruhl¹, Michael Albert Thomas¹

Magnetic Resonance Spectroscopy (MRS) allows noninvasive measurements of the concentration of metabolites in human breast in vivo. Two-dimensional (2D) MRS has improved resolution than one-dimensional (1D) MRS due to the additional J-coupling information in the second dimension. 2D COSY of breast tissues showed several metabolite and lipid ratios that are significantly different between different breast tissues. In this study we use classification and regression tree (CART) analysis for classification of four different breast tissues (malignant tumor, benign tumor, healthy fatty and healthy glandular tissues) based on the metabolite ratios from 2D COSY of breast tissues in vivo.