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Abstract #4328

Two-Dimensional Fitting for in Vivo NMR Spectra Quantification

Antonio Napolitano1, D Auer1, W Koeckenberger2

1Department of Academic Radiology, University of Nottingham, Nottingham, UK; 2SPMMRC, School of Physics and Astronomy, University of Nottingham, Nottingham, UK

The present work is based on the development and implementation of a software package that makes it possible to determinate both the absolute concentrations and the T2 values in a brain metabolite phantom. This method, implemented using MATLAB, has the advantage of computing the T2 values and performing an automatic correction of the concentrations by time relaxation. The output is then an absolute quantification determined by water reference and an estimation of spin-spin relaxation times of resonances of interest for in vivo spectroscopy.