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Abstract #4329

The Linear Relationship Between Cross-Peak Volume and Concentration of Metabolites in 2D Localized MR Spectroscopy

Hui Liu1, Jeon-Hor Chen1,2, Hyeon-Man Baek1, Mark J. Hamamura1, Seung-Hoon Ha1, Min-Ying Lydia Su1, Orhan Nalcioglu1

1Tu & Yuen Center for Functional Onco-Imaging, University of California, Irvine, CA, USA; 2Department of Radiology, China Medical University, Taichung, Taiwan

The linear relationship between the cross-peak volume and metabolite concentration measured by two-dimensional localized MR Spectroscopy was investigated. Phantom solutions containing five different concentrations (6, 10, 20, 40, 50 mM) of polyamine spermine, and another set of composite phantoms containing polyamine spermine, choline, and creatine with 20, 40, 60 mM were studied. The 2D L-COSY and 2D L-JPRESS were used to acquire the 2D spectra. The linear correlation coefficient between integrated cross-peak volume and metabolite concentration was between 0.97~0.99. Using the composite phantom we also show that the diagonal peak of creatine can be used as an internal reference.