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Abstract #0263

T1 Independent, T2* Corrected Chemical Shift Based Fat-Water Separation with Accurate Spectral Modeling Is an Accurate and Precise Measure of Liver Fat

Catherine D. G. Hines1, Alex P. Frydrychowicz2,3, Dana L. Tudorascu4, Gavin Hamilton5, Karl K. Vigen2, Huanzhou Yu6, Charles A. McKenzie7, Claude B. Sirlin5, Jean H. Brittain8, Scott B. Reeder1,2

1Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States; 2Radiology, University of Wisconsin-Madison, Madison, WI, United States; 3Diagnostic Radiology and Medical Physics, University Hospital Freiburg, Freiburg, Germany; 4Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin-Madison, Madison, WI, United States; 5Radiology, University of California-San Diego, San Diego, CA, United States; 6Applied Science Laboratory, GE Healthcare, Menlo Park, CA, United States; 7Medical Biophysics, University of Western Ontario, London, Ontario, Canada; 8Applied Science Laboratory, GE Healthcare, Madison, WI, United States

Accurate quantification of hepatic steatosis is essential for early detection of non-alcoholic fatty liver disease, which is increasingly common in Western societies. Quantitative IDEAL provides a means to measure hepatic steatosis in vivo, although its precision and accuracy are unknown. 40 patients were scanned twice using both quantitative IDEAL and MRS to assess accuracy and precision. Analysis of Bland-Altman plots, concordance correlation coefficients, linear regression and confidence intervals indicate that quantitative IDEAL provides both highly accurate and precise fat-fractions using MRS as a reference and is a reliable method of in vivo fat quantification.