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Abstract #0264

Echo Time Dependence of Laminar BOLD Activation at 7 Tesla

Peter Jan Koopmans1, Markus Barth1,2, David Gordon Norris1,2

1Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Netherlands; 2Erwin L. Hahn Institute for Magnetic Resonance Imaging, Essen, Germany

We present a multi-echo fMRI study at 7 T with 0.75 mm isotropic voxels and TEs ranging from 4.8 to 56 ms. Layer dependent T2* values are reported for human V1 showing a gradient from lower T2* near white matter and higher near the cortical surface with a superimposed dip in the granular layer. We show that the intravascular contribution to GE-BOLD at 7 T is dominated by the pial compartment and that laminar activation profiles are TE dependent. The optimal TE to detect BOLD changes in parenchyma is ~28 ms considerably longer than previously thought as previous estimates have included venous blood.