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Abstract #0265

Retinotopically Organized Left to Right Hemisphere Functional Connectivity in Human V1 Using High-Resolution FMRI at 7T

Jonathan Rizzo Polimeni1, Kyoko Fujimoto1, Bruce Fischl1,2, Douglas N. Greve1, Lawrence L. Wald1,3

1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA, United States; 2Computer Science and AI Lab (CSAIL), Massachusetts Institute of Technology, Cambridge, MA, United States; 3Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States

Functional connectivity analysis of resting-state fMRI data has been used to investigate large-scale networks of brain activity. Here investigate whether functional connectivity analysis exhibits sufficient spatial specificity to detect retinotopic organization of the cross-hemispheric correlations detected in cortical area V1. The observed pattern of functional connectivity follows the retinotopic layoutpresumably due to the retinotopically-organized common drive from the retina via the LGN. This indicates that despite the indirect nature of these inter-hemispheric connections, an orderly topographic pattern is present and functional connectivity analysis possesses the specificity to detect small-scale organization of the connections within a single cortical area.