Abstract #0265

Retinotopically Organized Left to Right Hemisphere Functional Connectivity in Human V1 Using High-Resolution FMRI at 7T

Jonathan Rizzo Polimeni¹, Kyoko Fujimoto¹, Bruce Fischl^1,2, Douglas N. Greve¹, Lawrence L. Wald^1,3

¹Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA, United States; ²Computer Science and AI Lab (CSAIL), Massachusetts Institute of Technology, Cambridge, MA, United States; ³Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States

Functional connectivity analysis of resting-state fMRI data has been used to investigate large-scale networks of brain activity. Here investigate whether functional connectivity analysis exhibits sufficient spatial specificity to detect retinotopic organization of the cross-hemispheric correlations detected in cortical area V1. The observed pattern of functional connectivity follows the retinotopic layoutpresumably due to the retinotopically-organized common drive from the retina via the LGN. This indicates that despite the indirect nature of these inter-hemispheric connections, an orderly topographic pattern is present and functional connectivity analysis possesses the specificity to detect small-scale organization of the connections within a single cortical area.