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Abstract #0840

Z-Spectroscopy with Phase Alternating Irradiation (ZAPI) in Articular Cartilage

Mikko Johannes Nissi1,2, Miika Tapio Nieminen3,4, Olli Heikki Grhn5, Johanna Nrvinen5

1Department of Physics, University of Kuopio, Kuopio, Finland; 2Department of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland; 3Department of Medical Technology, University of Oulu, Oulu, Finland; 4Department of Diagnostic Radiology, Oulu University Hospital , Oulu, Finland; 5Department of Neurobiology, A.I. Virtanen Institute for molecular Medicine, University of Kuopio, Kuopio, Finland

Exchange between collagen and bulk water in cartilage has been observed earlier in Magnetization transfer (MT) experiments. In the present study, the suitability of a recently introduced MT method, alternating phase irradiation Z-spectroscopy (ZAPI), in characterization of MT and T2 distribution in bovine cartilage was investigated. Use of alternating phase (AP) irradiation in ZAPI provides a unique possibility for T2 filtering by adjusting the pulse parameters. ZAPI was used for Z-spectroscopy and T2 filtered on-resonance MT of cartilage samples and the dependence of these parameters as a function of cartilage depth was analyzed.