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Abstract #0844

Improved Specificity of Cartilage Matrix Assessment Using Multiexponential T2 Parameter Maps with Validation by Fourier-Transform Infrared Spectroscopic Imaging

David A. Reiter1, Remy A. Roque1, Ping-Chang Lin1, Onyi Irrechukwu1, Nancy Pleshko2, Richard G. Spencer1

1National Institute on Aging, National Institutes of Health, Baltimore, MD, United States; 2Department of Mechanical Engineering, Temple University, Philadelphia, PA, United States

We sought to improve the specificity of cartilage matrix assessment through localized multiexponential T2 analysis permitting the mapping of matrix associated water compartments. Maps of MR-derived proteoglycan- (PG) bound water fractions (wPG) showed differences between young and mature cartilage; these differences were consistent with biochemically-derived PG content and Fourier-transform infrared spectroscopic imaging (FT-IRIS) derived PG content. Good spatial correspondence was observed between wPG maps and FT-IRIS-derived PG maps normalized by water content, demonstrating the potential of this approach to detect and map PG in degraded cartilage.