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Abstract #1003

Ex Vivo Assessment of Cervical Remodeling Via 23Na MRS

Xiang Xu1, Yucel Akgul2, Mala Mahendroo2, Alexej Jerschow1

1Department of Chemistry, New York University, New York, NY, United States; 2Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX, United States

Preterm birth occurs in 12.5% of births in the United States. Greater understanding by which the two main processes, uterine contraction and cervical remodeling are regulated is required to reduce rates of preterm birth. Understanding the changes in glycosaminoglycan (GAG) concentration during cervical remodeling will help elucidate the normal physiological process in the cervix. 23Na NMR spectroscopy is used to evaluate the changes in Na+ concentration in the mouse cervix during pregnancy, labor and postpartum as a means of evaluating the GAG changes during each stage of cervical remodeling.