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Abstract #1004

The 17O Imaging for Regional Oxygen Consumption Rate in Tumor Bearing Mice at 7T

Michiko Narazaki1, Yoko Kanazawa2, Hiroo Ikehira2, Tetsuya Matsuda1

1Kyoto University, Kyoto, Japan; 2National Institute of Radiological Sciences, Chiba, Japan

The tumor oxygen consumption rate in mice using 17O images was investigated. 17O FISP images were acquired before and after the inhalation of 17O enriched oxygen gas. The increment in the 17O image intensity due to the metabolically generated H217O from 17O2 was converted to the quantity of produced H217O, which was in good agreement with physiological data in literature. We confirmed this method promising as a tool for monitoring the oxygen consumption rate in tumor.