Meeting Banner
Abstract #1045

MR Microscopy of Zebrafish

Miriam Scadeng1, Ellen Breen2, Nathan Gray1, David Dubowitz1

1Radiology, UC San Diego, San Diego, CA, United States; 2Medicine, UC San Diego, San Diego, CA, United States

Being a relatively new animal model there is no comprehensive 3D anatomical atlas onto which temporal or spatial data can be projected. In addition, methods for in-vivo imaging of adult fish are needed if zebrafish researchers are to benefit from functional MR imaging techniques such as MRS, MEMRI, BOLD and even ASL that are routinely being used in mouse models of disease. The major challenges include the very small size of the fish, and imaging the live fish in water. We present methods for in-vivo MRI of zebrafish, and a 3D atlas of zebrafish anatomy.