Peter Andrew Hardy1, Zhiming Zhang1,
Don Gash1, Doug U. Gwost2, David Stiles2,
Brian D. Nelson2,
1Anatomy & Neurobiology, University
Convection Enhanced Delivery is a powerful method of delivering drugs to the CNS. We tested CED hardware and imaging methods by delivering Magnevist at three flow rates to the putamen in rhesus monkeys over a period of 7 days. T1-weighted images were acquired at three time points and from these the volume of distribution was characterized. Results demonstrate a compact distribution to the putamen with a flow rate-dependent volume.