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Abstract #1835

Convection Enhanced Delivery of Drugs to the CNS

Peter Andrew Hardy1, Zhiming Zhang1, Don Gash1, Doug U. Gwost2, David Stiles2, Brian D. Nelson2, Pei Ge3, Dinah Sah3

1Anatomy & Neurobiology, University of Kentucky, Lexington, KY, United States; 2Medtronic Neurological, Minneapolis, MN, United States; 3Alnylam Pharmaceuticals, Inc., Cambridge, Massachussets, United States

Convection Enhanced Delivery is a powerful method of delivering drugs to the CNS. We tested CED hardware and imaging methods by delivering Magnevist at three flow rates to the putamen in rhesus monkeys over a period of 7 days. T1-weighted images were acquired at three time points and from these the volume of distribution was characterized. Results demonstrate a compact distribution to the putamen with a flow rate-dependent volume.