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Abstract #1870

MR Cell Tracking in Reperfused Myocardial Infarction with Microvascular Obstruction and Haemorrhage: Fluorine-19 MR Could Be a Better Solution

Yuxiang Ye1, Thomas C. Basse-Luesekrink1, Paula Arias2, Kai Hu2, Thomas Kampf1, Vladimir Kocoski3, Xavier Helluy1, Peter M. Jakob1,4, Karl-Heinz Hiller1,4, Roland Jahns2, Wolfgang R. Bauer2

1Department for Experimental Physics 5, University of Wuerzburg, Wuerzburg, Bavaria, Germany; 2Deptment of Internal Medicine I, University Hospital Wuerzburg; 3Institute for Virology & Immunobiology, University of Wuerzburg, Germany; 4MRB Research Center, Magnetic-Resonance-Bavaria, Wuerzburg, Germany

MR Cell tracking with iron oxide labeling has high sensitivity but could be severely interfered by strong local magnetic susceptibility effects. We show that Fluorine-19 MRI could unambiguously detect blood monocytes/macrophages labeled with perfluorocarbon emulsion infiltrating the haemorrhagic myocardial infarct (MI) core both in vivo and ex vivo in a rat model at 7-T, despite the presence of strong local magnetic susceptibility effects caused by degraded hemoglobin products in microvascular obstruction or haemorrhage, which often occurs after reperfusion therapy . This finding suggests that Fluorine-19 MRI could be a better approach for MR cell tracking in where local T2* effects interfere the detection of magnetically labeled cells.