Divya Raman1, Anitha Priya Krishnan2,
Scott Kennedy3, John Olschowka4, Sammy N'dive2,
Delphine Davis5, Walter G. O'Dell2
1Biomedical Engineering, University of
Rochester, Rochester, NY, United States; 2Radiation Oncology,
University of Rochester, Rochester, NY, United States; 3Biophysics,
University of Rochester, Rochester, NY, United States; 4Neurobiology
and Anatomy, University of Rochester, Rochester, NY, United States; 5Imaging
Sciences, University of Rochester, Rochester, NY, United States
Our
hypothesis is that paths of elevated diffusion provide a preferred route for
migration of cancer cells away from primary tumor. This can be used to
improve radiation treatment of gliomas. Toward this end, we have developed a
computational model of cell migration based upon MR-DTI to predict
microscopic spread of cancer in patients. Objective of this work is to track
MPIO labeled rat glioma cells in rat brain and compare it to rat DTI model
and thereby demonstrate that tumor cells migrate farther from the site of
engraftment along major fiber tracts compared to gray matter.
Keywords