Toshiharu Nakai1, Makoto Miyakoshi1, Epifanio Bagarinao1, Chikako Nakai2, Kayako Matsuo3
1Functional Brain Imaging Lab, National Center for Geriatrics and Gerontology, Ohbu, Aichi, Japan; 2School of Health Sciences, Toyoshashi Sozo University, Toyohashi, Aichi; 3Psychology, National Taiwan University, Taipei, Taiwan
The characteristics of the hemodynamic response function underlying the age-related change was investigated to estimate its contribution to the statistical evaluation of fMRI by using motor tasks. It was suggested that the neuronal demanded was augmented to support cognitive processing for motor regulation rather than motor execution itself. Augmented activation in the elderly subjects mostly depended on the increased BOLD signal amplitude between the initial and post-stimulus peaks. It will be recommended to consider the potential bias induced by the non-linear dynamics of HRF to assess the age-related change of brain activation.