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Abstract #2017

Differences in GABA to Creatine Ratio Between the Occipital and the Medial Pre-Frontal Cortices

Jan Willem W. van der Veen1, Paul J. Carlson1, Jun Shen1

1NIH, NIMH, MAP, Bethesda, MD, United States

GABA and Glx were measured in 28 volunteers using a PRESS-based two step J editing sequence. Two voxels located in the medial prefrontal cortex (MPFC) and the occipital lobe (OCC) were studied. The GABA/Cre ratio was significantly higher (P<0.001) in the OCC (0.115 +/- 0.008) than in the MPFC (0.102 +/- 0.009). Co-edited Glx/Cre ratio was significantly (P<0.001) lower in the OCC (0.0806 +/- 0.006) than in the MPFC (0.0974 +/- 0.009). Our results, combined with previously reported Cre distribution in brain, show that there are significant differences in GABA and Glx between MPFC and OCC.