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Abstract #2040

Precision and Accuracy of Arterial Spin Labeling Perfusion MRI in the Pediatric Population

Varsha Jain1, Mariel Giannetta1, Michael Langham1, Sharon Xie1, Daniel Licht1, Joan Giannetta1, Timothy Roberts2, John Detre1, Hallam Hurt2, Felix Wehrli1, Jiongjiong Wang1

1University of Pennsylvania, Philadelphia, PA, United States; 2Children's Hospital of Philadelphia, Philadelphia, PA, United States

We evaluated the precision and accuracy of absolute CBF measurements using two arterial spin labeling (ASL) techniques, pulsed ASL (PASL) and pseudo-continuous ASL (pCASL) in a typical developing cohort of 18 healthy children 7 to 17 years old. Longitudinal reproducibility (precision) was assessed by repeated scans 2-4 weeks apart, while accuracy was assessed by comparison with total blood flow volume measured by phase-contrast (PC) MRI at the labeling plane. The results demonstrate excellent precision (ICC=0.62) and accuracy (ICC=0.77) of quantitative CBF measured by pCASL.