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Abstract #2186

Simultaneous Resting State FMRI and FET-PET

Irene Neuner1,2, Joachim Bernhard Maria Kaffanke1, Cornelius Werner1,2, Martina Reske1,3, Karl-Joseph Langen1, Hans Herzog1, N. Jon Shah1,2

1Institute of Neurosciences and Medicine 4, Medical Imaging Physics, Forschungszentrum Jlich GmbH, 52425 Juelich, Germany; 2Faculty of Medicine, Department of Neurology, RWTH Aachen University, 52074 Aachen, Germany; 3Department of Psychiatry, University of California San Diego, San Diego, CA, United States

For the planning of surgical intervention in human brain tumour cases, it is important to know if critical brain areas might be affected by the surgical process itself. PET imaging using radiolabelled amino acids is a valuable technique for the diagnosis of cerebral gliomas. O-(2-[18F]Fluorethyl)-L-Tyrosin (FET) is a well established amino acid tracer that delivers information about tumour extent, the optimal biopsy site and detection of tumour recurrences. In this study, FET-PET and BOLD-fMRI data were acquired simultaneously; data from a representative human brain tumour case are presented. In contrast to task-based functional studies, resting state fMRI offers the opportunity to detect a variety of cortical networks in a single experiment.