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Abstract #2226

Varied Vasomotor Responses Among Brain Territories in Unilateral ICA Stenosis Patients Studied Using Breath-Hold BOLD MRI

Wan Chun Kuan1, Ting Yu Chang2, Keh Shih Chuang1, Ho Fai Wong3, Tsong Hai Lee2, Ho Ling Liu4,5

1Dept. of Biomedical Engineering and Environmental Sciences, National Tsing Hua Univ., Hsinchu, Taiwan; 2Stroke Center, Department of Neurology, Chang Gung Memorial Hospital; 3Department of Neuroradiology, Chang Gung Memorial Hospital; 4Dept. of Medical Imaging and Radiological Sciences, Chang Gung Univ.; 5Dept. of Medical Imaging and Intervention, Chang Gung Memorial Hospital

Impaired cerebral vasoreactivity could be one of the predictors for hyperperfusion after carotid interventions for patients with internal carotid artery (ICA) stenosis. This study aimed to evaluate the differences of hemodynamic responses among blood-supply territories, induced by vasodilatation following a breath-holding task, in patients with unilateral ICA stenosis using BOLD MRI. The temporal correlation between bilateral vasomotor responses in the MCA territories was utilized as an index. The results showed significantly impaired responses of the lesion side as compared to the normal side (p<0.05) for patients exhibited hyperperfusion after the stenting (sensitivity = 100%, specificity = 92.3%).