Michael J. Stephen1, Kiarash Emami2,
John M. Woodburn2, Elaine Chia2, Stephen J. Kadlecek2,
Jianliang Zhu3, Masaru Ishii4,
1Department of Pulmonary and Critical Care, University of Pennsylvania, Philadelphia, PA, United States; 2Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States; 3Department of Surgery, VA Medical Center, Philadelphia, PA, United States; 4Department of Otolaryngology, Johns Hopkins University, Baltimore, MD, United States
This study demonstrates the first attempt to use hyperpolarized gas MR images of lung ventilation and apparent diffusion (ADC) in an animal model of interstitial lung disease. The efficacy of hyperpolarized 3He MRI metrics in assessing idiopathic pulmonary fibrosis (IPF) was evaluated in a bleomycin rat model. Results showed that fractional ventilation 3 weeks after bleomycin administration was significantly lower than in the control animals, and ADC measurements followed similar trends. Hyperpolarized gas MRI is a promising diagnostic for IPF and an improvement over current diagnostics in its regional sensitivity and benignancy.