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Abstract #2564

Regional Pulmonary Pressure Over Volume Curves of the Rat Lung Measured by Polarized 3He Magnetic Resonance Imaging

Angelos Kyriazis1,2, Ignacio Rodriguez1,2, Jose-Manuel Perez-Sanchez3, Lars E. Olsson4, Jesus Ruiz-Cabello1,2

1Universidad Complutense de Madrid, Instituto de Estudios Biofuncionales, Madrid, Spain; 2CIBER de Enfermedades Respiratorias, Spain; 3Orsay and Kremlin-Bicetre, U2R2M, Paris, France; 4DECS Imaging, AstraZeneca R&D, Mlndal, Sweden

A method to estimate regional lung volume over time based on spin-density 3He images is presented. Combining this with the tracheal pressure, regional volume over pressure is appraised. The static ROI are the left and the right lobe of the lung. Physiological parameters were calculated for the two ROI and for the whole lung. The method is proven reproducible because the measurements of the ROI of the same animal as well as the measurements of different animals agreed satisfactorily. The method may differentiate not only healthy from diseased animals but also healthy from diseased areas of the lung.