Angelos
Kyriazis1,2, Ignacio Rodriguez1,2, Jose-Manuel Perez-Sanchez3,
Lars E. Olsson4, Jesus Ruiz-Cabello1,2
1Universidad
Complutense de Madrid, Instituto de Estudios Biofuncionales, Madrid, Spain; 2CIBER
de Enfermedades Respiratorias, Spain; 3Orsay and Kremlin-Bicetre,
U2R2M, Paris, France; 4DECS Imaging, AstraZeneca R&D, Mlndal,
Sweden
A
method to estimate regional lung volume over time based on spin-density 3He
images is presented. Combining this with the tracheal pressure, regional
volume over pressure is appraised. The static ROI are the left and the right
lobe of the lung. Physiological parameters were calculated for the two ROI
and for the whole lung. The method is proven reproducible because the
measurements of the ROI of the same animal as well as the measurements of
different animals agreed satisfactorily. The method may differentiate not
only healthy from diseased animals but also healthy from diseased areas of
the lung.
Keywords