Meeting Banner
Abstract #2627

Metabolic Profilings of Urine from High Fat-Fed Rats Based on 1H NMR Metabolomics

Jingjing Xu1, Changqin Liu2, Shuhui Cai1, Jiyang Dong1, Zhong Chen1

1Department of Physics, Fujian Key Laboratory of Plasma and Magnetic Resonance, Xiamen University, Xiamen, Fujian, China; 2The First Hospital of Xiamen Affiliated to the Xiamen University, China

The biochemical variations of urine from chow- and high fat-fed rats were investigated using NMR-based metabolomics. Two groups can be discriminated clearly according to the scores plot of partial least squares discriminant analysis. The plot of variable importance in projection shows that taurine, succinate, hippurate, choline, citrate, dimethylamine, acetate, dimethylglycine, creatine, creatinine, tyrosine, glycine and lactate are contributed to the classification. In addition, the metabolic change with the development of obesity was also explored.