Wilhelm Zaiss1, Benjamin Schmitt1, Bram Stieltjes,
1Medical Physics in Radiology, DKFZ,
best method to evaluate magnetization transfer and chemical exchange transfer
are saturation transfer experiments with constant saturation power. Our
approach is a varying saturation power depending on the saturation offset.
Hereby, the solution of the Bloch-McConnell equations changes fundamentally.
Theoretical studies show that off-resonant pools can be isolated from the
water resonance while the intensity of the transfer effect remains unchanged.
Numerical simulations with pulsed saturation returned similar results. So,
the application on clinical scanners with pulsed saturation promises a more
robust way of measuring and evaluating z-spectra than common z-spectrum