Rebecca Sara Samson1, Matthew Clemence2,
Xavier G. Golay3, Claudia A M Wheeler-Kingshott1
1NMR Unit, Department of
Neuroinflammation, UCL Institute of Neurology, London, United Kingdom; 2Philips
Clinical Science Group, Philips Healthcare, Guildford, United Kingdom; 3NMR
Unit, Department of Brain Repair and Rehabilitation, UCL Institute of
Neurology, London, United Kingdom
RF
B1 transmit field non-uniformity, caused primarily by skin depth
and dielectric resonance effects, is a large source of error in quantitative
MR measurements made at 3.0T. We investigated the possibility that B1
errors could be reduced using dual transmission by measuring the MTR and B1
with and without dual transmission. We present preliminary data acquired on
three healthy subjects indicating that it may be possible to reduce
inter-subject variation in MTR histogram peak locations via the use of dual
transmission at 3.0T. This could be an important consideration when designing
future long-term clinical studies using quantitative MRI outcome measures.