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Abstract #3183

Towards a Dedicated DGEMRIC Protocol for Biochemical Imaging of the Menisci: Gd-DTPA(2-) Enhancement Kinetics in the Menisci of Asymptomatic Subjects

Marius E. Mayerhoefer1, Georg Riegler1, Tallal C. Mamisch2, Goetz H. Welsch1, Michael Weber1, Sebastian Apprich1, Siegfried Trattnig1

1Department of Radiology, MR Center, Medical University of Vienna, Vienna, Austria; 2Inselspital Bern, Switzerland

We investigated the Gd-DTPA(2-) enhancement kinetics within the menisci of the knee joint over a period of 9 hours in six healthy volunteers. T1-weighted spin-echo sequences were obtained in half-hour intervals at 3.0 Tesla. Menisci were divided into a peripheral zone (outer one-third; vascularized red zone), and a central zone (inner two-thirds; moderately vascularized intermediate zone, and avascular white zone). In the peripheral zones, the enhancement occurred more rapidly than in the central zones. We observed the strongest enhancement between 3 and 4 hours after contrast media application. This time interval may thus be suitable for dGEMRIC of the menisci.