Danchin Chen1, Dimitrios C. Karampinos1,2, Armen Gharibans1, Kevin F. King3, John G. Georgiadis1,2
1Mechanical Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States; 2Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States; 3GE Healthcare, Waukesha, WI, United States
Driven by the hypothesis that the secondary eigenvector field in DTI of skeletal muscle reflects the muscle ultrastructure transverse to fiber orientation, we superimpose the flow fields of the primary and secondary eigenvectors extracted from DTI data comprising axial slices of the mid-calf. V1 aligns with the local myofiber direction and the V2 field is topologically consistent with the putative orientation of the inter-myocellular force transmission. 3-D reconstruction of the eigenvector flow fields and consistency of the secondary eigenvector orientation in the proximodistal direction provide preliminary evidence of the presence of a woven fabric in skeletal muscle.