Abstract #3267

Dynamic Hyperpolarized C-13 Spectroscopic Imaging Using Radial Acquisition and HYPR Reconstruction

Kang Wang¹, Eric Peterson², Jeremy Gordon¹, Krishna Kurpad³, Ian Rowland³, Matthew Erickson³, Sean Fain¹

¹Medical Physics, University of Wisconsin-Madison, Madison, WI, United States; ²Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States; ³Radiology, University of Wisconsin-Madison, Madison, WI, United States

Hyperpolarized (HP) C-13 compounds exhibit non-equilibrium T1 decay and rapidly evolving spectral dynamics, and it is highly desirable to develop pulse sequences to image C-13 compounds in the spatial-spectral-time domain with high resolution in all dimensions. Non-Cartesian sampling methods, such as radial acquisition, are very attractive in this application due to their resistance to under-sampling artifacts. In this work, we proposed a radial acquisition method that is designed for HP C-13 time-resolved spectroscopic imaging and combined with HighlY constrained backPRojection reconstruction (HYPR).