Sadia Asghar Butt1, Lise Vejby Sgaard1,
Mette Hauge Lauritzen1, Jan Henrik Ardenkjr-Larsen2,
Lars H. Engelholm3, Susanne Holck4, Peter Magnusson1,
Per keson1
1Danish Research Centre for Magnetic
Resonance, Copenhagen University Hospital, Hvidovre, Denmark; 2GE
Healthcare, Hillerd, Denmark; 3Bartholin Institute, Copenhagen
Biocenter; 4Department of pathology, Copenhagen University
Hospital Hvidovre
There
is a need for monitoring of disease progression and treatment response in
breast cancer using metabolic biomarkers. We have applied the technique of
time resolved hyperpolarised 13C metabolic MRS to the transgenic mammary
cancer mouse model, MMTV-PymT. We use measurements of the lactate
dehydrogenase (LDH) rate constant reflecting the conversion of hyperpolarized
[1-13C]pyruvate to [1-13C]lactate in vivo to extract information about the
metabolic the status of the tissue Our
initial results show that we are able to monitor the changes in LDH kinetics
during tumour development and indicate
that the enzyme activity correlate to disease progression.