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Abstract #3367

NMR Spectroscopy of Urine for the Detection of Urinary Tract Infection (UTI) in Children

Tedros Bezabeh1, Omkar B. Ijare1, Martin Reed2, Tom Blydt-Hansen2, Ian C.P. Smith1

1National Research Council Institute for Biodiagnostics, Winnipeg, Manitoba, Canada; 2University of Manitoba Children's Hospital, Canada

Urinary tract infection (UTI) is the most common non-epidemic bacterial infection in adults and children. Due to the longer diagnostic wait time required for the gold standard the culture method, dipstick methods are commonly used for the quick diagnosis of UTI. However, dipstick methods are commonly associated with false negative and/or false positive results. Therefore, other more rapid methods are desirable. 1H NMR based metabolic profiling of urine samples could be valuable in this regard. Elevated levels of trimethylamine-N-oxide, creatine, and an unassigned signal at 3.71 ppm have been observed in the urine samples with UTI compared to the control group.